Whats your idea? FAB-144

Okay so we cant go back to 018 but if we could id love it and id staay there forever and ever!!! Butttt anyways whats your idea/ what do you think? Besides JWH-018 my favorite would be a smoking blend i made with;

ADB-CHMINACA MDMB-CHMICA FAB-144

Ratio 1:2

The ratio was roughly #.!/ grams of chem to 2 oz (56 grams) of dry herb.

Now the "High" was amazing, idk why but for some reason i just absolutely loved this blend. It just seemed so.... "PERFECT"...the come up wasnt too intense, and didnt keep building to the point where i was like "fuck im high" im gunna say COTTONMOUTH!!! Besides completely drying your mouth out, you do get the munchies like no other, i think i almost gained 10 pounds in 1 afternoon!!!! Lol ;p another thing good with these RC's is i never noticed a withdrawal from them and thats always a big thing about noids to me is how some are worse then fuckin heroin withdrawls, No Joke!!! But anyways i would give this blend of 3 Noids a try if i were you, i will say this tho, ADB-CHMINACA with FAB-144 IS MY ABSOLUTELY FAVOURITE!!!! THROW IN MDMB-CHMICA AND THAT JUST TAKES THE ICING RIGHT OFF MY NOID CAKE!!!!

WHAT ABOUT YOU? MY FELLOW NOIDS KING?!??!

Wow. Noids are freaking scary these days, I've never even heard of people making a cocktail of them. Are these three noids safe?

So question on that: what about their structures makes them so dangerous?

We have all these neurotoxic synthetic noids that cause seizures. And acting on the same receptors we have thc and cbd, both help TREAT seizures! And cbd is neurogenerative! What about their differences in action on the human body explain this night and day difference?

Honestly the fact that we can synthesize a huge number of noids that act on the cannabinoid receptors of our bodies that are so god-awful that they can give permanent brain damage with one dose, makes me wary of even natural cannabinoids. We know thc is relatively safe because there are a huge number of people that have done it for a very long time (however it does seem to affect working memory over time, and some people can develop depersonalization disorder). But all these minor cannabinoids in cannabis that they're breeding to obtain lots of these days: cbd, CBG, thcv, delta-8 Thc. Are these new cannabinoids that are becoming available through genetic breeding safe? How do we know they will not be neurotoxic like the synthetic noids?

Not to mention Yangonin in kavakava being smoked for the first time in the historical use of the plant, and polyphenols concentrated up in green tea extract taken as a dietary supplement. Both plants can cause liver damage if you take the extract in excess. The cannabinoid EGCG in green tea extract is to blame for the liver damage when it is taken in excess. I don't think we have narrowed down the kavakava liver damage to the cannabinoid Yangonin yet, but I wouldn't be surprised if it was the culprit.

Any thoughts on this?

Geez man I'm sorry that happened to you! I had no idea this stuff is as f***ed up as crack, but it really sounds like it is!

Echinacea has a CB2 agonist in it, with no CB1 activity, and it doesn't f*** your brain up. That being said, there are many cannabinoid receptors, and we are basically just starting to learn about the endocannabinoid system. So it is fair to say that we just don't know yet how the difference in shape between these molecules matters in how it affects us. You're probably right about the potency too, just having massively more of an affinity for our CB receptors makes it more toxic. Full vs partial agonist I've heard as well, but jwh-018 was a full agonist, and it didn't mess people up as badly as the noids out today.

I'm just freaked out that cannabinoids of any kind can do the sort of damage we're seeing. Sort of gives all cannabinoids even natural ones a marred reputation imo

I'll have to look up those papers, thank you!

Cannabinoids in green tea can be overdone enough to cause liver damage in a relatively easy to achieve dose.

But you're right so far I haven't heard of any from cannabis like that